【摘 要】
：
Plasmodium falciparum, the most fatal causative agent of human malaria, undergoes major remodeling of subcellular structures during its development and enco
【机 构】
：
MBGU, JNCASR, Bangalore, India
【出 处】
：
The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
Plasmodium falciparum, the most fatal causative agent of human malaria, undergoes major remodeling of subcellular structures during its development and encounters various conditions such as nutrient limitation, changes in pH, temperature and hypoxia during its complex life cycle.Autophagy is a regulatory process involved in mediating cellular differentiation and homeostasis in higher eukaryotes.Role of autophagy in Plasmodium falciparum is poorly understood and is controversial.We demonstrate that the constitutive autophagy in this parasite is quite robust and is essential for the development and differentiation of the parasite during the intraerythrocytic cycle.Further, the parasite responds to nutrient limitations.The expression of PfAtg8 is induced under starvation conditions for short durations while prolonged starvation results in decreased PfAtg8 expression and typical features of autophagy cell death.The starvation induced expression PfAtg8 is inhibited in presence of the autophagy inhibitor, 3-methyl adenine(3MA).We have also characterized other proteins present in autophagy machinery of Plasmodium falciparum.Thus deciphering the details of autophagy machinery of this apicomplexan might pave ways for novel therapeutics.
其他文献
Under starvation condition, cells degrade their own components by autophagy to supply nutritional sources for their survival.If starvation lasts for a long
At the upstream of yeast TORC1, a central regulatory factor of autophagy, there exists a hetero-dimeric G protein Gtr1/Gtr2 complex, which are homologues of
Autophagy is a major cellular machinery for the degradation of aggregated proteins via lysosome.Autophagy deregulation is closely associated with neurodegen
Rab proteins are key regulators of cellular trafficking in eukaryotic cells.Rab5 and Rab7 are endocytic Rab proteins functioning in modules to regulate vesi
Primary cilia are conserved cellular organelles that regulate diverse signaling pathways.Autophagy is a complex process of cellular degradation and recyclin
The main function of Leydig cells in the testis is to synthesize steroid sex hormone testosterone.Because autophagy is very active in the Leydig cells, it h
In S.cerevisiae the Cytoplasm to Vacuole Targeting (Cvt) pathway is a type of selective autophagy-related pathway, through which hydrolytic enzymes, like th
Autophagy is a bulk degradation pathway that clears macromolecules or whole organelles through double-layered membrane-bound autophagosomes.This conserved c
Defects in autophagy are observed in many diseases.They result from abnormal activity of lysosomal hydrolases or disturbances in the transport of material f
BNIP3 is regulated by hypoxia through hypoxia-inducible factor 1(HIF-1), which binds to hypoxia response element (HRE) in the promoter of BNIP3 and activate