【摘 要】
：
Autophagy is a bulk degradation pathway that clears macromolecules or whole organelles through double-layered membrane-bound autophagosomes.This conserved c
【机 构】
：
Department of Biological Sciences, National University of Singapore, Singapore 117543
【出 处】
：
The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
Autophagy is a bulk degradation pathway that clears macromolecules or whole organelles through double-layered membrane-bound autophagosomes.This conserved catabolic process promotes nutrient recycling and eukaryotic cell survival during starvation.All about 34 autophagy related genes (ATG) known to date were characterized in yeast, and studies in mammals have revealed a strong connection between autophagy and human diseases such as cancer, immuno-system disorder, type Ⅱ diabetes, infectious diseases and neurodegenarative diseases.In the evolutionarily divergent protozoan parasites that are highly relevant to human and animal diseases, increasing evidence is pointing towards a role of autophagy in infectious life cycle development and cell death.However, little is known about the regulation of autophagy in parasitic protozoa, preventing further attempts targeting this pathway for therapies.
其他文献
Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, have been associated with familial amyotrophic lateral sclerosis (fALS), which is a fatal ne
Fundamental and evolutionarily conserved role of autophagy is adaptation to starvation,however, the exact role of autophagy as nutrient recycle system remai
The Nrf2-Keap1 pathway provides cellular defense against oxidative stress by controlling the expression of antioxidant enzymes.One of noncanonical mechanism
Under starvation condition, cells degrade their own components by autophagy to supply nutritional sources for their survival.If starvation lasts for a long
At the upstream of yeast TORC1, a central regulatory factor of autophagy, there exists a hetero-dimeric G protein Gtr1/Gtr2 complex, which are homologues of
Autophagy is a major cellular machinery for the degradation of aggregated proteins via lysosome.Autophagy deregulation is closely associated with neurodegen
Rab proteins are key regulators of cellular trafficking in eukaryotic cells.Rab5 and Rab7 are endocytic Rab proteins functioning in modules to regulate vesi
Primary cilia are conserved cellular organelles that regulate diverse signaling pathways.Autophagy is a complex process of cellular degradation and recyclin
The main function of Leydig cells in the testis is to synthesize steroid sex hormone testosterone.Because autophagy is very active in the Leydig cells, it h
In S.cerevisiae the Cytoplasm to Vacuole Targeting (Cvt) pathway is a type of selective autophagy-related pathway, through which hydrolytic enzymes, like th