【摘 要】
：
Prolonged, unresolving inflammation is increasingly implicated in the pathogenesis of pancreatic cancer, but the critical inflammatory mediators remain largely
【机 构】
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CenterforVascularBiologyResearchandDepartmentofPathology,BethIsraelDeaconessMedicalCenter,HarvardMed
【出 处】
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2014 International Symposium on Polyunsaturated Fatty Acids
论文部分内容阅读
Prolonged, unresolving inflammation is increasingly implicated in the pathogenesis of pancreatic cancer, but the critical inflammatory mediators remain largely unknown.Most efforts to elucidate these mediators have focused on protein cytokines rather than lipid autacoids.Lipid autacoids are metabolites of arachidonic acid and other related fatty acids that regulate inflammation and tumor growth.Among these, the metabolites of the cytochrome P450 (CYP) epoxygenases and ω-hydroxylases, including EETs and 20-HETE,respectively, have been largely neglected in cancer.
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