Molecular mechanisms of Orai1-activation by STIM homologues--Dissecting Orai-coupling domains in STI

来源 :The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 | 被引量 : 0次 | 上传用户：meal09

【摘要】

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Store-operated Ca2+ entry (SOCE) is an ubiquitous cellular Ca2+ entry pathway and is essential in physiological Ca2+ signaling and homeostasis.SOCE is mainly me

【作者】

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Xizhuo Wang Youjun Wang Yandong Zhou Eunan Hendron Salvatore Mancarella Mark D.Andrake Brad S.Rothberg Jonathan Soboloff Donald L.Gill

【机构】

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DepartmentofBiochemistry,TempleUniversitySchoolofMedicine,Philadelphia,Pennsylvania19140,USADepartme

【出处】

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The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功

【发表日期】

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2014年7期

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Store-operated Ca2+ entry (SOCE) is an ubiquitous cellular Ca2+ entry pathway and is essential in physiological Ca2+ signaling and homeostasis.SOCE is mainly mediated by ER Ca2+ sensor STIM and calcium channel Oral on PM.Although STIM1 and STIM2 are structurally similar homologues, STIM2 has been shown to be more sensitive to store depletion and less effective in activating Orai.

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Molecular mechanisms of Orai1-activation by STIM homologues--Dissecting Orai-coupling domains in STI

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