【摘 要】
：
高HDL作用的烟酸基团引入具有降脂兼抗炎抗免疫作用的姜黄素类化合物中,形成的新型调脂抗炎化合物.采用分子模拟技术发现,CurNic与胆固醇转运相关蛋白质Caveolin-1、SREBP、P
【机 构】
：
湖南中医药大学干细胞中药调控与应用研究室,中药粉体与创新药物国家重点实验室培育基地
【出 处】
：
2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
高HDL作用的烟酸基团引入具有降脂兼抗炎抗免疫作用的姜黄素类化合物中,形成的新型调脂抗炎化合物.采用分子模拟技术发现,CurNic与胆固醇转运相关蛋白质Caveolin-1、SREBP、PCSK-9、Insig-1、ABC-A1、TLR-4及炎症因子NF-kB等都具有较高的对接(dock)效果,其LibDock值分别为134、181、138、 135、121、117和159.特别值得一提的是,CurNic可与PCSK-9形成2个氢键,提示CurNic可能干扰PCSP-9功能,调节LDL受体(LDL-R)降解.
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