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KSHV engages multiple host cell surface receptors such as heparan sulfate, integrins and EphrinA2 (EphA2), and activates receptor associated FAK, Src, PI3-K, c-Cbl, and RhoA GTPases signal molecules early during lipid raft (LR) dependant productive macropinocytic entry into HMVEC-d cells (PNAS 2012.109: E1163-72;Front Microbiol.2012.00006).