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Cancer stem cells (CSCs) are considered to be the root cause for cancer treatment failure.Thus,there remains an urgent need for more potent and safer therapies against CSCs for curing cancer.In this study,the antitumor activity of cytokine-induced killer (CIK) cells against putative CSCs of nasopharyngeal carcinoma (NPC) was fully evaluated in vitro and in vivo.To visualize putative CSCs in vitro by fluorescence imaging,and image and quantify putative CSCs in tumor xenograft-bearing mice by in vivo bioluminescence imaging,NPC cells were engineered with CSC detector vector encoding GFP and luciferase (Luc) under control of Nanog promoter.