【摘 要】
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Protein glycosylation is a vital cellular process which regulates the structure,location,stability and function of a protein.Asn-linked glycosylation (ALG) occurs only in eukaryotes.It has been estima
【机 构】
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Center for Biomedical Industries National Taipei University of Technology Taiwan
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Protein glycosylation is a vital cellular process which regulates the structure,location,stability and function of a protein.Asn-linked glycosylation (ALG) occurs only in eukaryotes.It has been estimated that 1% of the open reading frames of a genome are dedicated to this process.Although ALG is relative conservative in mammalian cells,there are several unique features found in protozoan parasites.First,the kinetoplastid Trypanosoma cruzi does not have glucosylated dolichol-PP-linked precursors.Second,a group of protozoa have truncated ALG precursors.Third,ALG from either Giardia lamblia (cause of diarrhea) or Plasmodium falicparum (cause of severe malaria) have non-mannosylated precusors.In this report,I describe additional uniqueness of N-linked glycans in protozoa via bioinformatics tools from genomewide screening.And,the validation of the in silico results via experimental data.The potential applications of the discovery will be discussed.
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