【摘 要】
：
Type 2 diabetes may be regarded as a risk factor for cancers in different sites.The aim of our study was to compare the progression of the oral cavity cancers in type 2 diabetic and non-diabetic patie
【机 构】
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Semmelweis University of Budapest Hungary
【出 处】
：
MIT`s 1st Annual World Congress of Diabetes-2012(2012第一届糖尿病大
论文部分内容阅读
Type 2 diabetes may be regarded as a risk factor for cancers in different sites.The aim of our study was to compare the progression of the oral cavity cancers in type 2 diabetic and non-diabetic patients.Prospective follow-up study involved patients with gingival squamous cell carcinoma in stage T2-3NOMO.Their treatment comprised surgical tumor exstirpation, block resection of the mandible, functional cervical dissection and 60 Gy adjuvant irradiation.Progression data was recorded after a 2 year period of clinical follow-up.Surgical samples were assessed histopathologically from the aspect of tumor spread.At the end ofa 2 year follow-up period, there were significantly worse clinical results in the diabetic group concerning the cervical lymph node metastases (P<0.05) and the rate of deaths (P<0.001).Histologically, the degree of tumor invasion was significantly more aggressive in the diabetic group compared to the controls (P<0.01).Type 2 diabetes can be regarded as a possible prognostic factor in cases of gingival carcinoma, forecasting an unfavourable course.
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