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Whole Body Vibration (WBV) is an innovative therapy that preliminary research has shown to be effective on chronic pain symptoms of diabetic peripheral neuropathy (DPN).However, no controlled, objective study of this has been conducted.Additionally, no studies have tested the effects of WBV on hemodynamics of the diabetic foot, which has been proposed as the etiology of the pain symptoms associated with DPN.PURPOSE: To test the efficacy of WBV on pain symptoms of DPN, motor nerve conduction velocity and blood flow in the diabetic foot.METHODS: 20 subjects (9 male, 11 female) with a mean age of 58.51± 10.69 yrs and a mean BMI of 33.60±8.20 kg/m2 were assigned to one of three groups: Control (n=3), treatment (n=12) and wait-list control (n=5).The subjects in the wait-list control group were allowed to begin the treatment after completing the control protocol.Treatment consisted of six vibration sessions over two weeks.Each vibration session consisted of 12 minutes of vibration broken up into 4 bouts of 3 minutes.The control protocol was identical but with sham vibration.Pain symptoms were assessed at each treatment using a 0-10 visual analog pain scale (VAS).Nerve function was assessed by measuring motor nerve conduction velocity (MNCV) of the posterior tibial nerve via electromyography using a surface stimulator probe.Toe-brachial index (TBI) was assessed by measuring systolic blood pressure at the brachial artery with a mercury cuff sphygmomanometer and at the great toe with a cuff and laser Doppler system and then determing the ratio of the two pressures.and MNCV were measured at both baseline and final treatment sessions.All variables were analyzed with a 2 (group) x 2 (time) repeated measure ANOVA, alpha was set at 0.05.RESULTS: Mean pain was reduced from 2.7±1.7 to 1.6±1.0, this reduction was significant both over time.and compared to the control (p=0.028).No significant difference was detected in the means for TBI or MNCV (p> 0.05) CONCLUSION: WBV is effective for reducing pain symptoms of DPN.However, these pain reductions are not concurrent with changes in motor nerve conduction velocity or in systolic blood pressure in the great toe.This indicates that cutaneous perfusion and motor nerve conduction are not affected by exposure to vibration.