【摘 要】
：
Activation of the DNA-damage response (DDR) can enable cancer cells to resist the lethal effects of genotoxic cancer therapy.However, cancer cells frequently exhibit defects in components of the DNA-d
【机 构】
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CRUK/MRC Oxford Institute for Radiation Oncology
【出 处】
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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
Activation of the DNA-damage response (DDR) can enable cancer cells to resist the lethal effects of genotoxic cancer therapy.However, cancer cells frequently exhibit defects in components of the DNA-damage response (DDR) and may consequently become highly dependent on remaining DDR pathways to survive DNA damage.Targeting such remaining DDR pathways has become a valuable new strategy for personalised cancer therapy, and an attractive target for this approach is the apical DDR kinase Ataxia-telangiectasia and Rad3-related (ATR).
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