CSB dependent homologous recombination at active transcription sites

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：wp87825385

【摘要】

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【作者】

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Li Lan

【机构】

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University of Pittsburgh,Pittsburgh,PA USA

【出处】

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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

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2015年3期

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Exposure to environmental pollutants, pesticides, or radiation inflicts oxidative DNA damage to the genome, which underlies the pathogenesis of many diseases.DNA double strand breaks (DSBs) are a frequent consequence of oxidative DNA damage.A severe blockade to RNA polymerase Ⅱ at sites of active transcription, DSBs have profound deleterious and mutational impact on cell survival and genome stability.

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CSB dependent homologous recombination at active transcription sites

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