MicroRNA-203 modulates olaparib sensitivity in medulloblastoma cells

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：bj_mark001

【摘要】

：

【作者】

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Okui Michiyo Junya Kobayashi Kenshi Komatsu Youngsoo Lee Peter J.Mc Kinnon

【机构】

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Toin University of Yokohama Kyoto University

【出处】

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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

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2015年3期

【关键词】

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PARP inhibitor microRNA

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　　Poly (ADP-ribose) polymerase-1 (PARP-1) serves as a critical enzyme in the repair of single-strand DNA breaks.PARP inhibitors (PARPi) can sensitize tumors to DNA-damaging agents and to selectively kill homologous recombination (HR)-deficient tumor cells, such those involving BRCA1/2 mutations.However, PARPi resistance frequently occurs, and therefore additional strategies that synergize with PARPi to enhance anti-tumor activity are necessary.

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MicroRNA-203 modulates olaparib sensitivity in medulloblastoma cells

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