【摘 要】
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Homologous recombination (HR) repairs double-strand breaks (DSBs) generated by radiotherapy and anti-cancer agents such as camptothecin and cisplatin.HR is initiated by DSB strand resection, where DSB
【出 处】
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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
Homologous recombination (HR) repairs double-strand breaks (DSBs) generated by radiotherapy and anti-cancer agents such as camptothecin and cisplatin.HR is initiated by DSB strand resection, where DSBs are processed by nucleases to generate 3single-strand DNA (3ssDNA), followed by the polymerization of Rad51 recombinase on the 3ssDNA.
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