Aurora Kinase B dependent 53BP1 Phosphorylation Is Essential to Resolve Merotelic Attachments during

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：romeolg

【摘要】

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【作者】

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Haibo Wang Bin Peng Raj K.Pandita David A.Engler Risё K.Matsunami Xingzhi Xu Pavana M.Hegde Tej K.Pandita Sankar Mitra Bo Xu Muralidhar L.Hegde

【机构】

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Department of Radiation Oncology,Houston Methodist Research Institute,Houston,TX 77030,USA;Houston M

【出处】

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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

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2015年3期

【关键词】

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53BP1 aneuploidy

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　　53BP 1 has been reported to have multiple roles in mammalian DNA damage response (DDR), specifically for repair of DNA double-strand breaks (DSBs) in an ATM-dependent manner that involves H2AX phosphorylation (γ H2AX) and recruitment of MDC1, RNF8,and RNF168.53BP1 is critical for nonhomologous end-joining (NHEJ)-mediated DNA DSB repair and has been implicated in the activation of intra-S-phase and G2/M checkpoints.

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