【摘 要】
：
As replication forks move across chromatin DNA, they frequently stall at hundreds to thousands of intrinsic replication barriers and DNA lesion sties.Stalled forks must require intra-S phase checkpoin
【机 构】
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Peking-Tsinghua Center for Life Sciences,The National Laboratory of Protein and Plant Gene Research,
【出 处】
：
The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
As replication forks move across chromatin DNA, they frequently stall at hundreds to thousands of intrinsic replication barriers and DNA lesion sties.Stalled forks must require intra-S phase checkpoint regulation for their stabilization.Otherwise, stalled forks collapse, which causes incomplete DNA synthesis, DNA breaks and a great varieties of genomic instability.
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