【摘 要】
：
Nijmegen breakage syndrome (NBS) as well as Ataxia Telangiectasia (A-T) is a radiation-hypersensitive genetic disorder, showing chromosomal instability, radioresistant DNA synthesis, and predispositio
【机 构】
：
Radiation Biology Center,Kyoto University,Japan R
【出 处】
：
The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
Nijmegen breakage syndrome (NBS) as well as Ataxia Telangiectasia (A-T) is a radiation-hypersensitive genetic disorder, showing chromosomal instability, radioresistant DNA synthesis, and predisposition to malignances.The product of responsible gene, NBS1 forms a complex with MRE11 and RAD50 (MRN complex).NBS1 also interacts with ATM upon generation of DNA double-strand breaks (DSBs), and this interaction is indispensable for sufficient ATM activation.So far, we identified other its interactions, with RNF20 (ubiquitin ligase for H2B), or Rad18 (ubiquitin ligase for PCNA).
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