【摘 要】
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Ataxia-Telangiectasia (A-T) is the most prominent among the inherited neuropathological disorders caused by defects in the DNA damage response pathway.Albeit neurodegeneration in A-T has initially bee
【机 构】
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Fondazione IRCCS Istituto Nazionale Tumori,DOSMM,Via Amadeo 42,20133 Milano,Italy
【出 处】
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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
Ataxia-Telangiectasia (A-T) is the most prominent among the inherited neuropathological disorders caused by defects in the DNA damage response pathway.Albeit neurodegeneration in A-T has initially been attributed to defective DDR signalling in pre-and post-mitotic neurons owing to ATM gene inactivation, oxidative stress and reduced anti-oxidant defence may also play a role, given the recently established function of ATM in redox signalling.
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