【摘 要】
：
The MRN (Mre11-Rad50-Nbs1) complex is well known for participating in DNA damage response pathways in all phases of cell cycle.Here we show that MRN constitutes a mitosis-specific complex, named mMRN,
【机 构】
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School of Life Science,Peking University,Beijing,China
【出 处】
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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
The MRN (Mre11-Rad50-Nbs1) complex is well known for participating in DNA damage response pathways in all phases of cell cycle.Here we show that MRN constitutes a mitosis-specific complex, named mMRN, with a novel protein, MMAP.MMAP directly interacts with MRE 11, and is required for optimal stability of the MRN complex during mitosis.MMAP co-localizes with MRN in mitotic spindles, and MMAP-deficient cells display abnormal spindle dynamics and chromosome segregation similar to MRN-deficient cells.
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