【摘 要】
：
The ATR-Chk1 pathway is critical for DNA damage responses and cell cycle progression.Chk 1 inhibition is more deleterious to cycling cells than ATR inhibition,raising questions about ATR and Chk1 func
【机 构】
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Massachusetts General Hospital Cancer Center Mass
【出 处】
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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
The ATR-Chk1 pathway is critical for DNA damage responses and cell cycle progression.Chk 1 inhibition is more deleterious to cycling cells than ATR inhibition,raising questions about ATR and Chk1 functions in the absence of extrinsic replication stress.Here, we show that a key role of ATR in S phase is to coordinate RRM2 accumulation and origin firing.
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