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It has been estimated that over one million people worldwide die from mosquito transmitted diseases every year.Control of mosquitoes largely depends on the use of harmful and costly chemical insecticides.Bti is one of the few Bacillus thuringiensis strains that are highly pathogenic to mosquito larvae and is widely used for control of mosquito populations.But application of this insecticide is limited,because of the high cost and its relatively low mosquitocidal activity,as compare with conventional pesticides.