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目的探讨甲壳低聚糖对高脂模型小鼠的降脂功效及其机理。方法采用高脂饲料连续饲养30 d建立小鼠高脂模型;同时,将壳聚糖酶解获得的甲壳低聚糖,以低、中、高(0.1、0.2、0.4 g·kg~(-1))3个不同的剂量分别给药。30 d后,眼眶取血,测血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)含量。结果甲壳低聚糖能显著降低高血脂小鼠血清中的TC、TG和LDL-C含量,并能升高HDL-C的含量。结论甲壳低聚糖调血脂生物活性较为显著,具有很好的开发前景。
Objective To investigate the hypolipidemic effect and mechanism of chitooligosaccharides on hyperlipidemia model mice. Methods Cholesterol oligosaccharides obtained by enzymatic hydrolysis of chitosan were cultured in high fat diets for 30 days. The chitooligosaccharides of low, medium and high (0.1, 0.2, 0.4 g · kg -1 )) Were administered separately at 3 different doses. Thirty days later, the orbital blood was taken for determination of the contents of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum. Results Chitooligosaccharides could significantly reduce the content of TC, TG and LDL-C in the serum of hyperlipidemic mice and increase the content of HDL-C. Conclusion Chitooligosaccharides blood lipid regulating biological activity is more significant, with good development prospects.