论文部分内容阅读
目的探讨甲状腺自身抗体预测妊娠期糖尿病患者自身免疫性甲状腺疾病的临床应用价值。方法选取2014年8-12月该院收治的孕满37周的孕妇为研究对象,其中常规甲状腺功能正常妊娠期糖尿病患者30例为观察组,健康孕妇30例为对照组。分析两组常规甲状腺激素指标和甲状腺自身抗体水平的差异。结果观察组血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)及促甲状腺激素(TSH)水平与对照组比较,差异无统计学意义(t=0.67、0.87、0.42,P均>0.05)。观察组甲状腺过氧化物酶抗体(TPOAb)阳性率、甲状腺球蛋白抗体(Tg Ab)阳性率及促甲状腺激素受体抗体(TRAb)阳性率均高于对照组,差异有统计学意义(χ2=8.3、12.1、9.7,P均<0.05)。结论采用常规甲状腺激素指标并不能灵敏地发现甲状腺功能变化及异常趋势,结合甲状腺自身抗体检测可以改善妊娠期糖尿病患者自身免疫性甲状腺疾病的临床预测效果。
Objective To investigate the clinical value of thyroid autoantibodies in predicting autoimmune thyroid disease in gestational diabetes mellitus patients. Methods Pregnant women of 37 weeks pregnant during the period from August to December in 2014 were enrolled in this study. Among them, 30 cases of normal thyroid function normal gestational diabetes mellitus were observed, and 30 healthy pregnant women were the control group. Analysis of two groups of conventional thyroid hormone and thyroid autoantibodies levels. Results There was no significant difference in serum free triiodothyronine (FT3), serum free thyroxine (FT4) and thyroid stimulating hormone (TSH) between the observation group and the control group (t = 0.67,0.87,0.42, P> 0.05). The positive rate of thyroid peroxidase antibody (TPOAb), the positive rate of thyroglobulin antibody (Tg Ab) and the positive rate of thyroid stimulating hormone receptor antibody (TRAb) in the observation group were significantly higher than those in the control group (χ2 = 8.3,12.1,9.7, P <0.05). Conclusion Conventional thyroid hormones can not detect thyroid function changes and abnormal trends sensitively. Combined with thyroid autoantibodies detection can improve the clinical predictive value of autoimmune thyroid disease in gestational diabetes mellitus patients.