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腹腔(25或50mg/kg)或侧脑室注射东莨菪碱(1mg/kg),均使大鼠的痛阈升高42—80%,并持续32—36小时之久。当在恒温室内作昼夜连续观察时,对照组的大鼠在深夜20时至次日8时之前,痛刺激反应稍有增强,此时东莨菪碱组的镇痛作用也相应地减弱,而白天的镇痛作用较强,似有昼夜规律的表现。东莨菪碱的镇痛作用与脑内阿片能系统无关,DA 能暂时增强其镇痛作用,毒扁豆碱能拮抗其镇痛作用,所以,东莨菪碱的镇痛作用,主要是阻滞中枢 M-胆碱能系统的作用所致。
Intraperitoneal (25 or 50 mg / kg) or intracerebroventricular injection of scopolamine (1 mg / kg) all increased the pain threshold in rats by 42-80% over a period of 32-36 hours. When observed continuously in day and night in a constant temperature room, the rats in the control group showed a slight increase in pain stimulus response from 20:00 in the evening to 8:00 am the following day. At this time, the analgesic effect of the scopolamine group was correspondingly weakened, while the daytime town Strong pain effect, seems to have the performance of day and night. Scopolamine analgesic effect has nothing to do with the brain opioid system, DA can temporarily enhance its analgesic effect, physostigmine can antagonize its analgesic effect, therefore, the analgesic effect of scopolamine, mainly block the central M-cholinergic The role of the system.