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蓮子心非結晶生物碱Nn-9对麻醉猫靜脉注射1-2毫克/公斤可降低原血压水平約50％,維持2-3小时。狗血压于1/2小时卽恢复,兔子不降压。有快速耐受性。經苯海拉明及异丙嗪处理猫再注射Nn-9碱2—3.5毫克/公斤,降压作用明显減弱。对靜脉注射組織胺引起的降压被Nn-9所減弱。猫靜脉注射2毫克/公斤的Nn-9后,血压下降伴随脑血管阻力減低,动脉注射0.2毫克/公斤使脑血流及后肢血流均增加,血管阻力減低。脊猫靜脉注射2毫克/公斤,有明显的降压出现。靜脉注射腎上腺素、去甲腎上腺素及脑垂体后叶素或在第七頸椎以下加高脊髓腔压所引起的升压反应均被抑制,历1/2—1小时恢复。电刺激頸交感神經节节前纤維所致的瞬膜收縮也受到抑制。对副交感神經节及M-胆碱反应系統无明显影响。頸动脉注射药液也出现降压,并抑制頸总动脉血流阻断所引起的升压反应。总結实驗結果,Nn-9的降压机制主要是释放組織胺,使外周血管扩张,其次神經因素也有关。
Lotus seed heart amorphous alkaloid Nn-9 anesthesia cat intravenous injection of 1-2 mg / kg can reduce the level of the original blood pressure about 50% for 2-3 hours. Dog blood pressure in ½ hours 卽 recovery, rabbits do not step down. Fast tolerance. After diphenhydramine and promethazine treatment, cats were injected with 2-3.5 mg / kg of Nn-9 alkali, and the antihypertensive effect was significantly weakened. Hypotension induced by intravenous histamine was attenuated by Nn-9. Cats intravenous injection of 2 mg / kg of Nn-9, decreased blood pressure accompanied by decreased cerebral vascular resistance, arterial injection of 0.2 mg / kg of cerebral blood flow and hind limb blood flow were increased, vascular resistance decreased. Ridge cats intravenous injection of 2 mg / kg, there is a clear buck appeared. Intravenous epinephrine, norepinephrine and pituitrin or lower cervical pressure in the seventh cervical spine caused by the antihypertensive response were inhibited, calendar 1 / 2-1 hours recovery. Electrical stimulation of cervical sympathetic ganglia preganglionic fibers caused by transient membrane contraction is also inhibited. Parasympathetic ganglia and M-choline reaction system had no significant effect. Carotid arterial injection also appears antihypertensive, and inhibit the common carotid artery blood flow caused by the anti-step-up response. Summary of experimental results, Nn-9 antihypertensive mechanism is mainly the release of histamine, the peripheral vasodilation, followed by neurological factors.