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药物在进入血液后,必须穿过一系列性质相似的细胞膜及亚细胞膜样结构,始能与所谓受体相作用产生药理效应。细胞表面的质膜、细胞器的膜及粒膜统称为生物膜。生物膜的主要功能为物质(包括药物)转运、能量转换、运动、识别及信息传递等。药物在体内的分布为一系列单层及复层的生物膜所阻遏,其中,细胞膜是影响药物分布的主要屏障。研究一个药物在组织、细胞中的转运和停留时间,对于深入了解该药的药理作用及为临床提供合理的用药方案均有很重要的意义。
After the drug enters the blood, it must pass through a series of similar cell membranes and subcellular membrane-like structures and begin to exert pharmacological effects on the so-called receptors. The plasma membrane on the cell surface, the membrane of the organelle, and the granuloma are collectively referred to as the biomembrane. Biofilm’s main function is material (including drug) transport, energy conversion, exercise, recognition and information transmission. The distribution of drugs in the body is blocked by a series of monolayer and multilayered biofilms, of which the cell membrane is the main barrier that affects drug distribution. To study the transport and residence time of a drug in tissues and cells is of great significance for understanding the pharmacological effects of the drug and providing a rational drug regimen for clinical use.