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目的:探讨高血糖对2型糖尿病患者认知功能的影响。方法:对135例2型糖尿病患者进行认知功能问卷,评定认知功能,同时测定问卷当日三餐前后及睡前血糖。比较不同血糖组间认知功能差异,并将空腹血糖(FPG)、餐后血糖(PPG)、最高血糖及平均血糖(MBG)与认知功能作相关性分析。结果:FPG≥6.1mmol/L和<6.1mmol/L组间、PPG≥10.0mmol/L组和<10.0mmol/L组间、最高血糖≥10.0mmol/L组和<10.0mmol/L组间认知功能差异均有显著性(P<0.05)。以日7次血糖平均值的中位数8.7mmol/L作为切点,≥8.7mmol/L组和<8.7mmol/L组间在MMSE定向、MMSE构图、听觉词语延时记忆等方面差异有显著性(P<0.05);FPG、PPG、最高血糖及MBG水平与认知功能均呈负相关关系。结论:高血糖可加重认知功能损害;空腹血糖≥6.1mmol/L或非空腹血糖≥10.0mmol/L就可出现认知功能减退;控制高血糖、减少血糖波动对保护认知功能有着重要意义。
Objective: To investigate the effect of hyperglycemia on cognitive function in type 2 diabetic patients. Methods: 135 cases of type 2 diabetes patients with cognitive function questionnaire, assessment of cognitive function, at the same time measuring the questionnaire on the day before and after meals and blood glucose before going to bed. The differences of cognitive function between different blood glucose groups were compared and the correlation between FPG, PPG, MBG and cognitive function was analyzed. Results: In the group of FPG≥6.1mmol / L, <6.1mmol / L, PPG≥10.0mmol / L and <10.0mmol / L, the highest glucose≥10.0mmol / L and <10.0mmol / L Knowledge of functional differences were significant (P <0.05). With the median of7mmol / L7months of daily blood glucose as the cut-off point, there were significant differences in the MMSE orientation, MMSE imaging and auditory verbal delay memory between8.7mmol / L group and <8.7mmol / L group (P <0.05). The levels of FPG, PPG, hyperglycemia and MBG were negatively correlated with cognitive function. CONCLUSION: Hyperglycemia may aggravate cognitive dysfunction. Fasting plasma glucose≥6.1mmol / L or non-fasting plasma glucose≥10.0mmol / L may cause cognitive decline. Controlling hyperglycemia and reducing blood glucose fluctuation are important for the protection of cognitive function .