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研究纳米羟基磷灰石(HAP)涂覆的多孔Mg-2Zn(质量分数,%)支架材料的生物降解能力和生物相容性。采用脉冲电沉积制备羟基磷灰石涂层。对涂覆HAP的支架在碱性溶液中进行后处理来改善其生物降解性和生物相容性。研究支架和HAP涂层的显微组织和成分以及它们在模拟体液(SBF)中的降解和细胞毒性。经过碱溶液处理后的涂层由几乎垂直于基体的直径小于100 nm的针状HAP组成,具有和天然骨头相似的成分,浸泡在SBF中后,产物为HAP、(Ca,Mg)3(PO4)2和Mg(OH)2。涂覆HAP和经过处理碱处理后的支架比未涂覆HAP的支架具有更高的生物相容性和细胞存活性。MG63细胞粘附在涂覆HAP和经过碱处理后的支架的表面并增殖,使这些支架有望应用于医学。结果表明:纳米HAP的脉冲电沉积和碱处理可有效改善多孔Mg-Zn支架的生物降解能力和生物相容性。
The biodegradability and biocompatibility of nano-hydroxyapatite (HAP) -coated porous Mg-2Zn (mass fraction,%) scaffolds were studied. Hydroxyapatite coatings were prepared by pulse electrodeposition. HAP-coated scaffolds are post-treated in an alkaline solution to improve their biodegradability and biocompatibility. Microstructure and composition of scaffolds and HAP coatings and their degradation and cytotoxicity in simulated body fluids (SBFs) were studied. After alkaline solution treatment, the coating consisted of acicular HAP with the diameter of less than 100 nm, which was almost perpendicular to the matrix. The coating had similar composition to the natural bone. After soaking in SBF, the product was HAP, (Ca, Mg) 3 ) 2 and Mg (OH) 2. Scaffolds coated with HAP and treated alkali had higher biocompatibility and cell viability than HAP-uncoated scaffolds. MG63 cells adhered to the surfaces of HAP-coated and alkali-treated scaffolds and proliferated, making these scaffolds promising applications in medicine. The results show that the pulsed electrodeposition and alkali treatment of nano-HAP can effectively improve the biodegradability and biocompatibility of porous Mg-Zn scaffolds.