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受试对象为1992年5月1日至9月15日出生于加拿大魁北克市6家产院的婴儿,出生体重均≥2500g,孕期至少36周。部分母亲在1957年以前出生(年龄≥35岁);部分在1967年后出生(年龄≤22岁)。分娩时分别采集母亲血和脐带血。受试婴儿在4和8月龄分别采血1份。
The subjects were infants born in 6 maternity homes in Quebec City, Canada from May 1 to September 15, 1992 with a birth weight ≥2500 g and at least 36 weeks of pregnancy. Some mothers were born before 1957 (age ≥35 years); some were born after 1967 (age ≤22 years). Maternal blood and umbilical cord blood were collected during childbirth. The infants tested 1 blood sample at 4 and 8 months of age respectively.