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番荔枝科植物依南木(Enantiachlorantha Oliv.)广泛分布于西、中非的森林中,其茎皮用于治疗溃疡,解热和抗疟疾。本文以生物活性为指导将其茎皮经提取,层析,从氯仿提取液中分得一个新的异喹啉生物碱—osupupine.经化学和光谱测定证实其结构为(1)。体外抗疟原虫试验表明:以原小檗碱类化合物药根碱氯化物(2)和巴马亭氯化物(3)作对照,本品(1)对耐氯喹的恶性疟原虫(Plasmodium falciparum)的活性优
Enantia chlorantha Oliv. is widely distributed in the forests of West and Central Africa. Its bark is used to treat ulcers, antipyretic and anti-malaria. In this paper, the bark was extracted and chromatographed on the basis of biological activity. A new isoquinoline alkaloid, osupupine, was isolated from the chloroform extract. The structure was confirmed by chemical and spectroscopic analysis (1). In vitro anti-Plasmodium test showed that the product (1) was resistant to chloroquine in Plasmodium falciparum using the original berberine compound jatrorrhizine chloride (2) and palmatine chloride (3) as a control. Excellent activity