论文部分内容阅读
本实验采用脑内注入自体抗凝血造成实验性大鼠脑出血模型,然后,用放射免疫法对各脑区的甲硫氨酸-脑啡肽(MET-ENK)含量进行测定。结果:纹状体在注血后即刻比对照组有显著性下降(P<0.01);海马在注血后1小时比对照组有显著性下降(P<0.05);中脑在注血即刻及1小时均比对照组有显著性下降(P<0.05)。注血24小时后,上述各脑区MET-ENK含量均恢复至正常水平。并与注血后引起的偏瘫等神经学体征的恢复相平行。本实验提示脑申的MET-ENK参与脑出血后的生化反应,并可能与偏瘫等神经学体征的出现有关。
In this study, experimental intracerebral hemorrhage was induced by intracerebral injection of autologous anticoagulant in rats. The content of methionine-enkephalin (MET-ENK) in each brain region was determined by radioimmunoassay. Results: Compared with the control group, the number of striatum decreased significantly (P <0.01), the hippocampus decreased significantly 1 hour after the injection (P <0.05) 1 hour than the control group were significantly decreased (P <0.05). After 24 hours of injection, the content of MET-ENK in each brain region recovered to normal level. And paralleled with the recovery of neurological signs such as hemiplegia caused by blood injection. This experiment suggests that MET-ENK in brain tissue may be involved in the biochemical reaction after intracerebral hemorrhage and may be related to the appearance of neurological signs such as hemiplegia.