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选择高颅压型脑囊虫病患者23例,男20例,女3例,年龄8~57岁,平均37.7岁,病程5月~17年,平均11个月。其诊断均符合脑囊虫病诊断标准(中华神经精神科杂志1986;19:376.),且具有高颅压的临床表现和体征。3例行脑室引流术,术后死亡1例,有效率66.7%。20例内科治疗。治疗时先用20%甘露醇500~1500ml/日并氟美松10~20mg/日静脉滴注,颅压下降后加用丙硫咪唑或吡喹酮0.6~1.2/日,一个疗程7~15日。若驱虫过程中出现副反应则立即停用驱虫药,继续降颅压,待反应消失后再重新用药。个别颅压下降者可椎管内注射氟美松10~20mg/次,每周2~3次,经1~6次后,颅压可明显下降。经3~8个疗程治疗,17例有效,有效率85%。高颅压型脑囊虫病临床并非少见,但因部分医师对该病缺乏认识而造成误诊。故详细询问病上并行头颅CT和酶免检查是防止误诊的重要手段。治疗上对于脑室内囊虫引起脑脊液循环障碍或并发脑和水者可手术治疗,术后仍需驱虫治疗。而驱虫治疗,国内采用的剂量和疗程不一。认为大剂量多疗程治疗可达到有效的杀虫作用。为减少副作用发生,可先用脱水剂和激素静点或椎管内注射激素,颅压控制后再加用作用温和的丙硫咪唑,由小剂量至1.2/日,若反应轻微则可酌情改用作用强的吡喹酮治?
Twenty-three patients with hypertensive intracranial cysticercosis were selected, including 20 males and 3 females, aged from 8 to 57 years (mean 37.7 years). The course of disease ranged from May to 17 years with an average of 11 months. The diagnosis is in line with the diagnostic criteria for cysticercosis (Chinese Journal of Neurology and Psychiatry 1986; 19: 376.), And with high intracranial pressure clinical manifestations and signs. 3 cases ventricular drainage, postoperative death in 1 case, the effective rate of 66.7%. 20 cases of medical treatment. Treatment with 20% mannitol 500 ~ 1500ml / day and flumethasone 10 ~ 20mg / day intravenous infusion of intracranial pressure plus propranolol or praziquantel 0.6 ~ 1.2 / day, a Course of 7 to 15 days. If the deworming process side reactions immediately deactivator, continue to reduce intracranial pressure, until the reaction disappears and then re-medication. Individual intracranial pressure may be intracameral injections of dexamethasone 10 ~ 20mg / times, 2 to 3 times a week, after 1 to 6 times, intracranial pressure can be significantly decreased. After 3 to 8 courses of treatment, 17 cases were effective, effective rate of 85%. High intracranial pressure type cysticercosis clinical is not uncommon, but because some doctors lack of understanding of the disease caused misdiagnosis. Therefore, in detail ask the disease head CT and enzyme-free examination is to prevent misdiagnosis of an important means. Treatment for intracapsular cysticercosis caused by cerebrospinal fluid circulation or brain and water may be surgical treatment, still need deworming treatment. The deworming treatment, the domestic dose and treatment vary. That large doses of multiple courses of treatment can achieve effective insecticidal effect. In order to reduce the occurrence of side effects, dehydration agents and hormones can be used intravenous or spinal injection of hormones, intracranial pressure control and then add the role of moderate albendazole, from a small dose to 1.2 / day, if the reaction may be mild Where appropriate, use strong praziquantel treatment?