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目的探讨血清高敏C-反应蛋白(high sensitivity C-reactive protein,hsCRP)水平与结直肠癌患病风险相关性。方法结直肠癌组选取病理资料和hsCRP资料完善的86例结直肠癌患者,对照组来源于同期在开滦总医院行健康体检社区健康居民,采用随机抽样方法,依照性别与年龄1∶2匹配,共172例。采用多因素Logistic回归分析hsCRP水平与结直肠癌患病的风险(OR)及其95%可信区间(CI)。结果结直肠癌组和对照组hsCRP水平呈非正态分布,分别为1.79(0.1~20.5)mg/L、0.77(0.05~16.5)mg/L,结直肠癌组hsCRP水平高于对照组,差异有统计学意义(P<0.05)。调整吸烟、饮酒与体育锻炼后,多因素Logistic回归分析结果显示,hsCRP第三分位组患结直肠癌的风险是第一分位组的3.26倍(95%CI为1.26~10.31)。结论血清hsCRP水平可能与结直肠癌患病风险有关。
Objective To investigate the correlation between the serum hsCRP level and the risk of colorectal cancer. Methods Totally 86 cases of colorectal cancer with pathological data and hsCRP data were selected from the colorectal cancer group. The control group was derived from the health check-up community residents in Kailuan General Hospital during the same period. The patients were randomly selected according to their sex and age 1: 2 , A total of 172 cases. Multivariate logistic regression was used to analyze the association between hsCRP level and the risk of colorectal cancer (OR) and its 95% confidence interval (CI). Results The hsCRP levels in colorectal cancer group and control group were non-normal distribution, which were 1.79 (0.1-20.5) mg / L and 0.77 (0.05-16.5) mg / L, respectively. The hsCRP level in colorectal cancer group was higher than that in control group There was statistical significance (P <0.05). Logistic regression analysis of multivariate logistic regression analysis showed that the risk of colorectal cancer in hsCRP third tertiles was 3.26 times (95% CI, 1.26-10.31) in the first quintile. Conclusion Serum hsCRP level may be related to the risk of colorectal cancer.