论文部分内容阅读
[目的]观察糖骨康方联合碳酸钙D_3治疗血瘀型糖尿病骨质疏松症疗效。[方法]使用随机平行对照方法,将80例住院及门诊患者按抽签简单随机分两组。对照组40例碳酸钙D_3,0.6g/次,1次/d。治疗组40例糖骨康方(丹参20g,桃仁10g,红花3g,当归15g,三七10g,熟地、秦艽、骨碎补、淫羊藿、牛膝、枸杞子、黄芪各15g);碳酸钙D_3治疗同对照组。连续治疗6个月为1疗程。观测临床症状、骨密度、总Ⅰ型原胶原N-延长肽(PINP)、β-胶原降解产物(CTX)、骨痛VAS评分、骨折发生率、不良反应。治疗1疗程,判定疗效。[结果]骨密度、骨转换指标、骨痛VAS评分治疗组明显改善(P<0.05),对照组无明显变化(P>0.05)。骨折发生率两组间无明显差异(P>0.05)。[结论]糖骨康方联合碳酸钙D_3治疗血瘀型糖尿病骨质疏松症,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Tanggukangfang combined with calcium carbonate D_3 on blood stasis type diabetic osteoporosis. [Methods] Using randomized parallel control method, 80 inpatients and outpatients were randomly divided into two groups according to random sampling. Control group, 40 cases of calcium carbonate D_3, 0.6g / time, 1 time / d. Treatment group, 40 cases of sugar GuKangFang (Salvia 20g, peach 10g, safflower 3g, Angelica 15g, notoginseng 10g, Rehmannia, Gentiana, Drynaria, Epimedium, Achyranthes, medlar, Astragalus each 15g) Calcium D_3 treatment with the control group. Continuous treatment of 6 months for a course of treatment. Clinical symptoms, BMD, total type Ⅰ procollagen (PINP), β-collagen degradation product (CTX), VAS score, fracture incidence and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] The bone mineral density, bone turnover index and VAS score of pain were significantly improved in the treatment group (P <0.05), but there was no significant change in the control group (P> 0.05). There was no significant difference between the two groups in the incidence of fracture (P> 0.05). [Conclusion] Tanggukangfang combined with calcium carbonate D_3 in treating blood stasis type diabetic osteoporosis has satisfactory curative effect and no serious adverse reactions, which deserves promotion.