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目的:观察舌下含服卡前列甲酯栓预防剖宫产妇产后出血的有效性和安全性。方法:存在出血高危因素的剖宫产妇62例随机分为观察组与对照组各31例,观察组于第二产程末胎头娩出前,舌下含服卡前列甲酯栓1 mg;对照组在胎儿娩出后静注催产素20 u。观察两组患者术中、术后2 h出血量和总出血量,用药前后血压变化,及治疗期间药品不良反应发生情况。结果:观察组术中、术后2 h及总出血量均明显低于对照组(P<0.05);两组治疗前后的收缩压及舒张压变化比较,差异均无统计学意义(P>0.05)。治疗后观察组不良反应发生率9.7%,对照组未见不良反应发生。结论:舌下含服卡前列甲酯栓可明显减少出血高危因素产妇剖宫产术中、术后出血量,且安全性较高。
Objective: To observe the effectiveness and safety of sublingual submandibular ester plug in preventing postpartum hemorrhage of cesarean section. Methods: 62 cases of cesarean section with bleeding risk factors were randomly divided into observation group and control group of 31 cases, the observation group in the second stage of labor at the end of the first childbirth, sublingual card captopril suppository 1 mg; control Group intravenous injection of oxytocin 20 u after delivery of the fetus. The intraoperative and postoperative 2 h blood loss and total blood loss, blood pressure changes before and after treatment, and the occurrence of adverse drug reactions during the treatment were observed. Results: The intraoperative and postoperative 2 h and the total amount of bleeding in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups before and after treatment (P> 0.05 ). After treatment, the incidence of adverse reactions in the observation group was 9.7%, and no adverse reactions occurred in the control group. CONCLUSIONS: Sublingual administration of procatresulfame acetate suppositories can significantly reduce the amount of bleeding after cesarean section and postoperative bleeding at high risk of bleeding, and is safe.