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目的:探讨地诺前列酮栓用于妊娠晚期引产的效果极其安全性。方法:妊娠晚期患者360例随机分为观察组和对照组各180例。对照组采用缩宫素引产,观察组采用地诺前列酮栓引产。比较两组患者用药前后的宫颈Bishop评分、宫颈成熟率、临床效果、引产成功率、临产时间、分娩方式、新生儿结局及不良反应情况差异。结果:用药后两组Bishop评分均较前显著增加(P<0.05),且观察组评分更优于对照组(P<0.05)。观察组的宫颈成熟率、引产成功率、临产时间、阴道分娩率等各方面均显著优于对照组(P<0.05)。两组临床效果比较,观察组的显效率(45%)、总有效率(95%)均显著高于对照组(P<0.05)。观察组产后出血明显少于对照组(P<0.05),两组宫内窘迫、宫缩过强、新生儿Apgar评分等比较,差异无统计学意义(P>0.05)。结论:地诺前列酮栓用于妊娠晚期引产,能显著的提高宫颈成熟、引产成功率等指标,节省临产时间,减少产后出血,效果优于催产素。
Objective: To investigate the effect of dinoprostone suppository on the efficacy of induction of labor in the third trimester of pregnancy. Methods: 360 cases of late pregnancy were randomly divided into observation group and control group of 180 cases. The control group was treated with oxytocin and the droperidol was given to the observation group. The Bishop cervical score, cervical ripening rate, clinical effect, success rate of induced labor, duration of labor, mode of delivery, neonatal outcome and adverse reactions were compared between the two groups before and after treatment. Results: The Bishop scores of both groups were significantly increased (P <0.05), and the score of the observation group was better than that of the control group (P <0.05). The observation group’s cervical maturation rate, the success rate of induction of labor, labor time, vaginal delivery rate and other aspects were significantly better than the control group (P <0.05). The two groups of clinical effects, the observation group markedly effective (45%), the total effective rate (95%) were significantly higher than the control group (P <0.05). Postpartum hemorrhage in the observation group was significantly less than that in the control group (P <0.05). There was no significant difference between the two groups in terms of intrauterine distress, uterine contractions and Apgar score in neonates (P> 0.05). CONCLUSION: The use of dinoprost suppository in induction of labor during the third trimester of pregnancy can significantly improve the indexes of cervical ripening and induction of labor, save labor time and reduce postpartum hemorrhage, which is superior to oxytocin.