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本文对226例系统性红斑狼疮病人平均随访观察了46个月,发现其中91例(40%)患有雷诺氏现象。虽然一般认为该症状常见于疾病的早期,但本文有1/3病例是在起病后较晚的病程中出现的。雷诺氏现象在黑种人要比白种人及拉丁美洲人较为少见。关节炎、颊部皮疹及光敏感性等症状在有雷诺氏现象的病人要比无雷诺氏现象的病人更为常见,但是其他临床及血清学表现包括骨无菌性坏死则与病人有无雷诺氏现象无关。肾脏病变在有或无雷诺氏现象的病人中发病率相等,但是在血清肌酐量超过3毫克/毫升及肌酐清除率低于60毫克/分钟的严重肾脏
In this paper, 226 patients with systemic lupus erythematosus were followed up for an average of 46 months and found that 91 (40%) patients had Raynaud’s phenomenon. While it is generally accepted that this condition is common in the early stages of the disease, one third of the cases in this article appear in the later course of the disease. Raynaud’s phenomenon is less common in blacks than in Caucasians and Latinos. Symptoms such as arthritis, buccal rashes, and light sensitivity are more common in patients with Raynaud’s disease than in patients without Raynaud’s phenomenon, but other clinical and serological manifestations include bone aseptic necrosis with or without Renault The phenomenon has nothing to do. The incidence of kidney disease is the same in patients with and without Raynaud’s disease but in severe kidneys with a serum creatinine excess of 3 mg / mL and creatinine clearance of less than 60 mg / min