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作者以间接免疫荧光法检查16例SLE患者病损处皮肤,并以DLE3例、大疱性类天疱疮4例、银屑病及正常人各1例以及10例SLE患者无病损皮肤活检作对照。结果在所有SLE患者病损皮肤的表皮、真皮交界处和血管周围沉积有C型HEL-12病毒的免疫复合物,对照组全部阴性,且吸收试验〔以3微克C型HEL-12病毒及60微克抗原类似的猴肉瘤病毒(SiSV),狒狒内源性病毒(BaEV),吸收含HEL-12型病毒抗体的血清后再检查则不能见到该复合物,说明反应被阻断。而以无抗原关系的Rous肉瘤病毒的Schmidt-Ruppin株(SRRSV)吸收,虽高达60微克的量也不能阻断〕确定此反应具特异性。此外以人血清白蛋白,免疫球蛋白及小牛血清等吸收也不能阻断其反应,加以作者
The authors examined 16 cases of SLE patients with indirect immunofluorescence lesions of the skin, and to DLE3 cases, 4 cases of bullous pemphigus, 1 case of psoriasis and normal and 10 cases of SLE patients without skin biopsy As a control. Results Immunocomplexes of type C HEL-12 virus were deposited on the skin, dermis junction and perivascular area of diseased skin of all patients with SLE, and all the controls were negative. Absorption test (3 μg HEL-12 and 60 The microtitre antigen-like monkey sarcoma virus (SiSV), baboon endogenous virus (BaEV), the absorption of serum containing HEL-12 antibody can not be seen after re-examination of the complex, indicating that the reaction was blocked. Whereas the Schmidt-Ruppin strain (SRRSV) of the Rous sarcoma virus, which is not antigenic, can not be blocked up to an amount of 60 micrograms, confirming the specificity of this reaction. In addition to human serum albumin, immunoglobulin and bovine serum absorption can not block its response, to be the author