论文部分内容阅读
外周血液甲状腺激素包括甲状腺素(T_4)、3,5,3′,三碘甲腺原氨酸(T_s)、及新近发现无生理活性的3,3′,5反三碘甲腺原氨酸(rT_3)。己知从T_4转为T_3和rT_3的降解均需碘化甲腺氨酸5′—脱碘酶催化,后者主要存在于肝、肾细胞微粒体及原浆膜。肝脏病人这种酶活性降低使血中T_3减少而无活性的rT_3增加。故测定血清T_3、T_4、rT_3及rT_3:T_3比值结合其它有关生化检查有助于肝功及预后的评价。作者用放射免疫法分别对活检及实验室检查确诊的29名酒精性肝硬化(其中11例合
Peripheral blood thyroid hormones include thyroxine (T_4), 3,5,3 ’, triiodothyronine (T_s), and newly found physiologically inactive 3,3’, 5-triiodothyronine (rT_3). Known from T_4 to T_3 and rT_3 degradation are required methyidin iodide 5’-deiodinase catalysis, the latter mainly in the liver, renal cell microsomes and plasma membrane. This decrease in enzyme activity in liver patients results in an increase in rT_3 with less T_3 in blood and no activity. Therefore, the determination of serum T_3, T_4, rT_3 and rT_3: T_3 ratio combined with other biochemical tests contribute to the evaluation of liver function and prognosis. The authors used radioimmunoassay to detect biopsy and laboratory tests of 29 patients with alcoholic cirrhosis (including 11 cases of combined