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恶性肿瘤患者后期常出现的衰弱等体症表明,肿瘤可能影响宿主的能量代谢。弄清楚肿瘤对宿主能量代谢的影响机制,在理论和实践上都有意义。 щалот等证明患有某些非肝部肿瘤的动物,其肝线粒体的氧化磷酸化效率(P/O)较正常者低。Nanni等曾报告患Sacoma肉瘤大鼠的血清能使正常肝线粒体的P/O比值下降。但对其机理并未进一步研究。我们以正常大鼠及小鼠肝线粒体为材料,系统地观察了患艾氏腹水癌(EAC),U-14、S-180小鼠血清和患腹水型Walker256大鼠血清对上述线粒体的呼吸强度、呼吸控制率(RCR)、P/O比值,腺三磷(ATP)酶及对线粒体膜结构的影响。并对其机制进行了讨论。
Malnutrition patients often appear later in the body such as weakness that the tumor may affect the host’s energy metabolism. To clarify the mechanism of the tumor on the energy metabolism of the host, both in theory and in practice have meaning. щалот and other animals that demonstrate certain non-hepatic tumors have lower rates of oxidative phosphorylation (P / O) in liver mitochondria than in normal subjects. Nanni et al. Reported that serum from Sacoma sarcoma rats decreased the P / O ratio of normal liver mitochondria. But its mechanism has not been further studied. Using normal rat and mouse liver mitochondria as materials, we systematically observed the respiratory intensity of these mitochondria in sera from patients with Ehrlich ascites carcinoma (EAC), U-14, S-180 and ascites-derived Walker256 , Respiratory control rate (RCR), P / O ratio, adenosine triphosphate (ATP) enzyme and mitochondrial membrane structure. And discussed its mechanism.