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近年来,随着放射性同位素免疫定量测定甲状腺激素的发展,对一些临床上非甲状腺疾病的病人进行了有关甲状腺素(T_4)、三碘甲状腺原氨酸(T-3)及甲状腺功能的研究,发现在肝脏疾病时甲状腺激素有一定的变化,引起了人们的重视。本文拟对肝脏严重病变时,甲状腺功能的变化进行综述。正常人肝脏与甲状腺激素的代谢正常人的甲状腺受垂体分泌的促甲状腺素(TSH)控制,TSH依赖下丘脑分泌的促甲状腺释放激素(TRH)的作用。甲状腺主要分泌四碘甲状腺原氨酸(即甲状腺素,T_4),每天约为100nmole,其次也分泌T_3,T_3每天分泌量为
In recent years, along with the development of thyroid hormones by radioimmunoassay, thyroid hormone (T_4), triiodothyronine (T-3) and thyroid function have been studied in some patients with clinical non-thyroid disease. Found in the liver disease, thyroid hormone has a certain change, aroused people’s attention. This article is intended to review the changes of thyroid function in severe liver disease. Normal human liver and thyroid hormone metabolism Normal human thyroid secretion by the pituitary thyroid hormone (TSH) control, TSH-dependent hypothalamic secretion of thyrotropin-releasing hormone (TRH) role. Thyroid secretion of four primary iodine thyroxine (ie thyroid hormone, T_4), about 100nmole every day, followed by secretion of T_3, T_3 secretion per day