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78例不同类型的癫痫单用丙戊酸钠治疗,并借助于血药浓度和脑电图监测,64％患者的发作得到了完全控制或基本控制。丙戊酸钠对失神性和强直-阵挛性发作的疗效(显效率>90％)明显优于对部分性发作的疗效(显效率37％);并对脑电图上的普遍性痫样放电有显著的抑制作用。在治疗剂量10-30mg/(kg·d)范围内,未发现严重的毒副反应。本研究确定的丙戊酸有效血浓度为30-80μg/ml;经常监测血浓度,有利于提高疗效和减少毒副反应。
Seventy-eight different types of epilepsy were treated with sodium valproate alone and with the aid of plasma concentrations and EEG monitoring, complete or substantial control was achieved in 64% of patients with seizures. Valproate sodium for deafness and tonic - clonic seizures (markedly effective rate> 90%) was significantly better than the partial seizures (markedly effective rate of 37%); and on the EEG epileptic Discharge has a significant inhibitory effect. In the treatment dose of 10-30mg / (kg · d), no serious side effects were found. In this study, the effective blood concentration of valproic acid was 30-80μg / ml; regular monitoring of blood concentration, help to improve the efficacy and reduce side effects.