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美国自1970年开始试用阿霉素,在二千余病例中研究了药物的剂量范围、药理学和毒理学。发现阿霉素至少对十四种不同类型的肿瘤有效。除了研究单独用药外,还对阿霉素与其它药物的合并治疗作了观察。第一期临床研究最常使用的方案是间歇脉冲治疗。在许多单位,开始以每3～4周给阿霉素3～4天为一疗程,并证明骨髓功能正常的患者可以
The United States has been experimenting with doxorubicin since 1970 and has studied the dose range, pharmacology, and toxicology of drugs in more than 2,000 cases. Doxorubicin was found to be effective against at least fourteen different types of tumors. In addition to studying the use of drugs alone, the combined treatment of adriamycin and other drugs was also observed. The most commonly used protocol in Phase I clinical studies is intermittent pulse therapy. In many units, treatment with doxorubicin is started every 3 to 4 weeks for 3 to 4 days, and patients with normal bone marrow function can