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早在十九世纪初,已有人注意到肠病与肌骨骼系统症状有联系。1920年,Smith 认为肠道感染可引起“风湿病”,以结肠切除术或回肠-乙状结肠吻合术治疗68例,使症状明显改善。1935年,Hench 描述了发生于溃疡性结肠炎(溃结)的外周关节炎,并注意到关节症状常与溃结发作相关。1959年后,Dright 等许多作者进一步确定了炎症性肠病伴发关节炎的临床、血清学、X 线等特征。肠病性外周关节炎炎症性肠病伴有外周关节炎者占15～20%,男女发病几乎相等。Haslock 等报告Cr-ohn 病伴关节炎占20%,溃结中约12%,Crohn病累及结肠者则更高。Farmer 等报告Crohn病结肠型、小肠型、回结肠型的关节炎发病率分别为16、4、3.6%。关节症状常与肠病病情加重同时发生。在溃结病人,全结肠切除可防止关节症状复发,但这对Crohn 病一般无效。因此,有
As early as the early nineteenth century, it has been noticed that there is a link between enteropathy and musculoskeletal symptoms. In 1920, Smith concluded that intestinal infections could cause “rheumatism” and that 68 patients underwent colorectomy or ileo-sigmoid anastomosis, leading to a significant improvement in symptoms. In 1935, Hench described peripheral arthritis that occurs in ulcerative colitis (UC) and noted that joint symptoms often correlate with the onset of UC. After 1959, many authors such as Dright further defined the clinical, serological and X-ray features of inflammatory bowel disease associated with arthritis. Enteropathic peripheral arthritis Inflammatory bowel disease with peripheral arthritis accounted for 15 to 20%, almost the same incidence of men and women. Haslock et al. Reported that Cr-ohn disease accounts for 20% of arthritis, about 12% of patients with ulceration, and Crohn’s disease is more involved in the colon. Farmer and other reports of Crohn’s disease colon, small intestine, enterocolitis incidence of arthritis were 16,4,3.6%. Joint symptoms and enteropathy often aggravate simultaneously. In patients with ulceration, total colon resection can prevent the recurrence of joint symptoms, but this is generally not valid for Crohn’s disease. So, yes