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文献报道红细胞膜表面可能有裂殖子受体,当它被蛋白质消化处理后可阻止裂殖子侵入红细胞。作者利用这一特性对疟原虫侵入红细胞机理进行了研究。感染恶性疟原虫的红细胞经同步化处理使其仅含环状体,再用胰蛋白酶或链霉蛋白酶等处理,发现这样的处理并不影响环状体的发育但可使红细胞抑制新的裂殖子侵入。同时,如加入未经处理的红细胞,则可观察到有大量新裂殖子侵入。由此不仅巧妙地提供了分离裂殖子的方法并使有可能研究裂殖子侵入与红细胞成分之间的关系。胰凝乳蛋白酶处理人红细胞并不能阻止裂殖子的侵入。用化学方法如以作用于氨基的活性试剂H_2DIDS或交链剂
It has been reported in the literature that merozoite receptors may be present on the surface of erythrocyte membrane, which can prevent merozoites from invading red blood cells when it is digested by proteins. The authors used this property to study the mechanism of malaria parasite invasion of red blood cells. Erythrocytes infected with P. falciparum were synchronized to contain only the annulus and then treated with trypsin or pronase and found that such treatment did not affect the development of the annulus but allowed the erythrocytes to inhibit new meronisms Sub intrusion. In the meantime, if untreated erythrocytes are added, a large amount of neoplasm invasion can be observed. This not only cleverly provided a method of separating merozoites and made it possible to study the relationship between merozoite invasion and erythrocyte composition. Chymotrypsin treatment of human erythrocytes does not prevent the invasion of merozoites. Chemically, for example, acting as an active agent on the amino group, H 2 DIDS or a crosslinking agent