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目的探讨阿托伐他汀在治疗急性脑梗死患者的临床疗效及预后影响。方法 60例急性脑梗死患者,根据治疗药物不同分为对照组和观察组,每组30例。对照组给予降压、降糖、改善脑循环、抗血小板治疗等常规治疗。观察组在对照组基础上加用阿托伐他汀治疗。比较两组患者治疗前后的低密度脂蛋白-胆固醇(LDL-C)、高脂血症(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)变化情况。在治疗前与治疗后6周给予两组患者采用美国国立卫生研究院卒中量表(NIHSS)评定功能状况。结果观察组患者基本治愈9例(30.00%),显著进步13例(43.33%),进步6例(20.00%),无变化1例(3.33%),恶化1例(3.33%),治疗总有效率为93.33%;对照组患者基本治愈5例(16.67%),显著进步8例(26.67%),进步10例(33.33%),无变化5例(16.67%),恶化2例(6.67%),治疗总有效率为76.67%,比较差异具有统计学意义(P<0.05)。治疗后两组患者的TC、TG、LDL-C、HDL-C指标比较治疗前均有明显下降,差异有统计学意义(P<0.05),且观察组指标下降比对照组更加明显,差异有统计学意义(P<0.05)。结论阿托伐他汀可有效降低血脂、改善动脉粥样硬化等,对治疗急性脑梗死及其预后均有显著作用。
Objective To investigate the clinical efficacy and prognosis of atorvastatin in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were divided into control group and observation group according to the different therapeutic drugs, 30 cases in each group. Control group given antihypertensive, hypoglycemic, improve cerebral circulation, antiplatelet therapy and other routine treatment. The observation group was treated with atorvastatin on the basis of the control group. The changes of LDL-C, TG, TC and HDL-C before and after treatment were compared between the two groups. Both groups before and 6 weeks after treatment were assessed for functional status using the National Institutes of Health Stroke Scale (NIHSS). Results The patients in the observation group were cured basically in 9 cases (30.00%), 13 cases (43.33%) were significantly improved, 6 cases (20.3%) were improved, 1 case The efficiency was 93.33%. The patients in the control group were cured basically in 5 cases (16.67%), significantly improved in 8 cases (26.67%), improved in 10 cases (33.33%), unchanged in 5 cases (16.67% , The total effective rate was 76.67%, the difference was statistically significant (P <0.05). The levels of TC, TG, LDL-C and HDL-C in the two groups after treatment were significantly decreased compared with those before treatment (P <0.05), and the decrease in the observation group was more obvious than that in the control group Statistical significance (P <0.05). Conclusions Atorvastatin can effectively reduce blood lipids, improve atherosclerosis and so on, for the treatment of acute cerebral infarction and its prognosis have a significant role.