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为研究微生物批式流加发酵生产1,3-丙二醇的动力学模型.采用分阶段描述的方法,考虑细胞内甘油、3羟基丙醛、1,3丙二醇的浓度变化,将整个批式流加发酵过程分成若干个间歇和连续流加的阶段.在连续流加阶段,将流加速度看成是随时间变化的函数,依此改进非线性动力系统,分析系统的性质.最后建立参数辨识模型,利用粒子群算法求解.数值计算结果表明:改进后的模型的平均相对误差比现有文献降低3%~5%.这说明改进后的非线性多阶段动力系统比较适合描述微生物批式流加发酵过程.
In order to study the kinetic model of 1,3-propanediol produced by batch fermentation in micro-organisms, the concentration of glycerol, 3-hydroxypropionaldehyde and 1,3-propanediol in the cells was determined by the staged description method, The fermentation process is divided into a number of intermittent and continuous flow stage.In the continuous flow stage, the flow acceleration as a function of time, thus improving the nonlinear dynamic system, the analysis of the nature of the system.Finally, the establishment of parameter identification model, The results of numerical calculation show that the average relative error of the improved model is 3% ~ 5% lower than the existing literature, which shows that the improved nonlinear multi-stage dynamic system is more suitable for the description of microbial batch-fed fermentation process.