,Highly diversified Zika viruses imported to China, 2016

• 作 者: Yanjun Zhang Wenxian Chen Gary Wong Yuhai Bi Juying Yan Yi Sun Enfu Chen
• 机 构: Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China“,”Yiwu Center fo
• 出 处: 蛋白质与细胞
• 发表日期: 2016年6期

Dear Editor,First discovered during 1947 in Uganda from febrile rhesus macaques,Zika virus (ZIKV) is a mosquito-bome,reemerging flavivirus historically known to be present in much of Africa and Asia,occasionally causing outbreaks amongst the local populace (Haddow et al.,2012).ZIKV infections in humans are mostly asymptomatic,but a small percentage of patients may show clinical symptoms such as a fever and rash,which resolve within a week or less.Due to the benign nature of the disease,ZIKV was considered an obscure and neglected pathogen of low public health consequence.Recently,viral infection of women during pregnancy have been associated with microcephaly in their offspring (Ventura et al.,2016),and neurological disorders such as Guillain-Barré syndrome (GBS) have also been associated with prior ZIKV infections (Cao-Lormeau et al.,2016).Moreover,the ZIKV nonstructural protein 1 (NS1) has diverse electrostatic characteristics at host-interaction interfaces (Song et al.,2016).These new findings,in addition to the persistence of ZIKV in the semen of infected patients (Lazear and Diamond 2016) and possible sexual transmission of the virus (Oster et al.,2016) suggest that this virus may be more dangerous than initially thought.