【摘 要】
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Dear Editor,Influenza virus is a member of the Orthomyxoviridae family and is the causative agent of seasonal and pandemic flu.There are three types of influenz
【机 构】
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CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology, Chinese Acad
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Dear Editor,Influenza virus is a member of the Orthomyxoviridae family and is the causative agent of seasonal and pandemic flu.There are three types of influenza virus: A, B and C.Influenza A viruses possess the greatest host-range and reassortment ability and all known influenza pandemics have been caused by type A.Influenza A viruses contain 8 negative-strand RNA segments, encoding 14 proteins, including 3 major surface proteins, hemagglutinin (HA), neuraminidase (NA) and the M2 proton channel.Due to their accessibility on the surface of the virus, HA, NA and M2 have been the primary targets for the design of anti-influenza therapeutics (Du et al., 2012).
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