【摘 要】
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Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor (GEF) that is synergistically activated by G-protein coupled receptors and receptor tyr
【机 构】
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Department of Pharmacology,Creighton University School of Medicine,Omaha,NE 68178,USA“,”National Lab
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Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor (GEF) that is synergistically activated by G-protein coupled receptors and receptor tyrosine kinases (Welch et al.,2002).We previously reported that aberrantly upreguiated P-Rex1 promotes prostate cancer metastasis by activating Rac1 signals (Qin et al.,2009).P-Rex1 is also highly overexpressed in estrogen receptor-positive and ErbB2-overexpressing human luminal breast tumors,which correlates with the aggressiveness of human breast cancer and poor outcome in breast cancer patients (Montero et al.,2011;Sosa et al.,2010).Silence of endogenous P-Rex1 blocks breast cancer cell proliferation,tumorigenesis,and motility (Montero et al.,2011;Sosa et al.,2010).Therefore,P-Rex1 is an important mediator in cancer progression and could be a potential therapeutic target.
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